Journal of Kerman University of Medical Sciences

The Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients

Document Type : Original Article

Authors

A.R Nik seresht 1
B Dadkhah 2
E Kamali sarvestani 3

1 Associate Professor of Neurology, School of Medicine and Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Resident of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Professor of Immunology, School of Medicine and Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract
Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients with MS and 292 ethnically and sex matched controls were included in this study. BsmI polymorphism in VDR gene was assessed by PCR-RFLP method. Results: No differences in the allelic distribution were observed in the patients as compared to the controls. Also no difference in genotype distribution of VDR-BsmI polymorphism was observed between patients and controls (p=0.43). Conclusion: Considering the significance of vitamin D3 as an immune system regulator and its inhibitory effects on MS, investigation on other VDR gene polymorphisms is recommended.

Keywords

Multiple Sclerosis
Vitamin D
Polymorphism
Iran
Journal of Kerman University of Medical Sciences
Volume 16, Issue 4
2009
Pages 116-123

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