Giant Cell Reparative Granuloma (G.C.R.G) of the Maxillary Sinus (Brown Tumor): a Case Report and Review of Literature

Document Type : Case Report


Associate Professor of Otorhinolaryngology, Kerman University of Medical Sciences and Health Services, Kerman, Iran


The patient is a seventheen years old girl, with severe pain and swelling in right maxillary sinus region and facial deformity from two weeks prior to referring. CT scan demonstrated a large tumoral mass in right maxillary sinus extended to petereigomaxillary fossa, orbital floor, lacrimal system and nasoethmoid region. Hard palate had been destroyed and bulged in to the oral cavity. Tumor was resected completely by radical cald-well-luck approach. Hystopathology of tumor was giant cell reparative granuloma (G.C.R.G), which is a very rare tumor in paranasal sinuses. Since the association of these tumors with hyperparathyroidism has been reported in literature, the patient was evaluated for hyperparathyroidism and elevated serum parathyroid hormone (PTH: 390 pg/ml) and other hematological tests confirmed secondary hyperparathyroidism.