Among 17786 karyotyres performed in our center,during 18 years (1357-1375),1300(7.3%) cases of chromosome 21 aberration,including 1284(98.77%) of Down syndrome have been detected.1191 of cases (92.76%) born free trisomy 21:61 cases (4.75%) revealed translocation and 32 cases (2.4%) showed mosaic pattern.among the pateints,59 had robertsonian translocation,2 had translocation between chromosome 21 and a non acrocentric chromosome designated as chromosomes 7 and 8.among the 1284 patients with chromosome 21 aberration,735 were male and 549 female with a Mto F ratio of 1.34:1-cytogenetic study of 18 parents of DS children with robertsonian translocation revealed that 4 cases(22.22%) were inherited from the carrier mothers.there were also 4 translocation in non G chromosomes,which were inherited from either parent.in general 8 of the 23 parents(34.78%) including 6 mothers and 2 fathers transmitted the involved chromosome to their children in the other 15 cases primary translocation occured.two of the DS were also associated with klinfelter syndrome (48,XXY+21) and one male child born 47,XY+21, 5p+Cri du chat).our findings are almost similar to the large group studies of other investigators.
Kariminejhad, M., Kariminejhad, R., Azimi, F., Nabavi nia, N., Alavi, K., Takyar, M., Shafeghati, Y. (1997). Cytogenetic analysis of 1284 cases of Down syndrome. Journal of Kerman University of Medical Sciences, 4(1), 7-16.
MLA
M.H Kariminejhad; R Kariminejhad; F Azimi; N Nabavi nia; K Alavi; M.T Takyar; Y Shafeghati. "Cytogenetic analysis of 1284 cases of Down syndrome". Journal of Kerman University of Medical Sciences, 4, 1, 1997, 7-16.
HARVARD
Kariminejhad, M., Kariminejhad, R., Azimi, F., Nabavi nia, N., Alavi, K., Takyar, M., Shafeghati, Y. (1997). 'Cytogenetic analysis of 1284 cases of Down syndrome', Journal of Kerman University of Medical Sciences, 4(1), pp. 7-16.
VANCOUVER
Kariminejhad, M., Kariminejhad, R., Azimi, F., Nabavi nia, N., Alavi, K., Takyar, M., Shafeghati, Y. Cytogenetic analysis of 1284 cases of Down syndrome. Journal of Kerman University of Medical Sciences, 1997; 4(1): 7-16.
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