Document Type : Original Article
Authors
ssociate professor
Abstract
The aim of this study was to Investigate the toxic effects of chromium and cadmium on the activity of two isoenzymes of alkaline phosphatase in vitro and in vivo experiments. Oral administration and peritoneal injection of CdCl2 or CrCl3 in rats reduced serum alkaline phosphatase by 21.5℅ and 25.5℅ respectively. At the same time high molecular weight alkaline phosphatase was elevated by 138℅ and 333℅ , and low molecular weight alkaline phosphatase was reduced by 30 or 40 percent. The in vitro experiments indicated that CdCl2 or CdCl3 lead to the reduction of activity of both isoenzymes of alkaline phosphatase.
Keywords
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