The Effect of Pistacia Atlantica Extract and Aerobic Training on the Levels of Triiodothyronine, Thyroxine and Lipid Profile in Streptozotocin-Diabetic Rats

Document Type : Original Article


1 Associate Professor, Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran

2 Master of Science, Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran

3 Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran

4 Master of Science Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran


Background: Diabetes is considered as one of the health problems in all societies. Exercise training and herbal medicines are some approaches to improve diabetes. The present study investigated the effect of a six weeks exercise training program and/or Pistacia atlantica (mastic) extract on thyroid hormones and lipid profile as well as antidiabetic effects in diabetic rats.
Methods: Forty male Wistar rats were randomly divided into five groups: Healthy control (Ctrl), diabetic control (D), Diabetic + exercise (DE), Diabetic + mastic extract (DM) and Diabetic + exercise + mastic extract (DEM). The six-week period exercise program included aerobic training on a treadmill (five sessions per week, 40 minutes per each session, with a speed of 20 m/min and 5% incline). Pistacia atlantica extract was fed 5 days per week (25 mg/kg). Forty eight hours after the last training session, the level of T3, T4, triglyceride, cholesterol and HDL were assessed.
Results:Triglyceride levels in DEM group was significantly lower than diabetic group (p <0.05). The mean level of cholesterol and HDL (high density lipoprotein) was not significantly different among groups. Plasma concentration of T
and T
in diabetic control was significantly lower than normal control. Applying mastic extract alone or together with exercise markedly enhanced T4 levels in diabetic rats.
Conclusion: Pistacia atlantica extract and exercise training might be good in the improvement of hypothyroidism and hyperlipidemia resulting from diabetes.


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