Journal of Kerman University of Medical Sciences

Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients

Document Type : Original Article

Authors

Hossein Ali Ebrahimi meimand 1
Farhad Iranmanesh 1
Mahdi Ansari 2
Hasibeh Molla Mohammadi 3
Sepideh Ebrahimi 3

1 Professor of Neurology, Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Professor of Pharmacology, Kerman University of Medical Sciences, Kerman, Iran

3 Medical Student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

https://doi.org/10.22062/jkmu.2020.90640
Abstract
Background:epilepsy is one of the common neurological disorders and approximately
0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy in refractory epileptic patients.
Methods: Two groups of epileptic patients (n=21) were selected randomly. Group 1 received lactose as a placebo, and group 2 received L-arginine (twofold of daily need) as a drug for three months. We used a standard questionnaire for evaluating the effect of L-arginine on the quality of life before and after the study.
Results: we did not find significant change in the quality of life of patients after using L-arginine, but the epileptic attacks decreased in L-arginine group significantly.
Conclusion: L-arginine therapy is safe and can decrease the rate of seizure attacks in refractory epileptic patients, and can be an alternative of ketogenic diets.

Keywords

L
arginine Refractory epilepsy Epilepsy Ketogenic diets
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Journal of Kerman University of Medical Sciences
Volume 27, Issue 3
May and June 2020
Pages 213-221

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