Advances in Stem Cell Therapy Based on Tissue Engineering in the Treatment of Female Infertility with a Focus on POF

Document Type : Review Article


1 Deptartement of Anatomy, Faculty o Medecine, Social Development & Health Promotion Research Center, Gonabad University of MedicalScience, Gonabad, Iran

2 School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran & Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

3 Department of Anatomy, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

4 Department of Anatomy, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran

5 Department of Physiology, Faculty of Medicine, Social Development & Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran

6 Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


Background: In the last few decades, many studies have been done on the treatment of premature ovarian failure. This review was conducted to study different types of treatment with a focus on the 3D culture model of stem cells as a pluripotent source for repairment in regenerative medicine for this disease in recent decades.
Methods: To conduct this review, electronic databases of MEDLINE, Scopus, PubMed, and Web of Science were searched using MeSH terms. Only English articles were included, and case reports were excluded. The keywords used for the search were mentioned as the keywords of the paper.
Results: To transplant the stem cells into the patient's body, the 3D culture of these cells in vitro and the molecular and cellular aspects of these cells were considered, andtheir success rate and differentiation were compared to granulosa cells or oocytes.
Conclusion: The present study aimed to discuss the potential effects of stem cells for regeneration and recovery of ovarian function in premature ovarian failure as a useful therapy.


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