Document Type : Original Article

Authors

Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University of Kerman, Kerman, Iran

Abstract

Background: This study aimed to investigate the validity and reliability of the updating component tasks of executive functions in normal individuals and to compare their performance with patients with clinical disorders, including schizophrenia (SC), traumatic brain injury (TBI), Alzheimer’s disease (AD), and major depressive disorder (MDD).
Methods: In this causal-comparative study, all normal individuals aged 16-70 years and patients with SC, TBI, AD, and MDD in Kerman city, were included. The study population included 406 normal individuals who were selected through convenience sampling and 74 patients (24 SC, 11 TBI, 15 AD, and 24 MDD) who were selected by purposive sampling. Participants completed updating tasks, including letter memory, keep track, spatial 2-back, and spatial 3-back. Data were analyzed using descriptive statistics, Cronbach’s alpha, test-retest reliability, and multivariate analysis of variance.
Results: The results showed that the validity and reliability of the updating tasks are acceptable, and there is a significant difference between the scores of normal individuals and those of patients with SC, TBI, AD, and MDD.
Conclusion: According to the results, it can be concluded that this set of tasks can well assess the updating-specific ability and distinguish between the performance of normal individuals and patients with clinical disorders.

Keywords

  1. Cristofori I, Cohen-Zimerman S, Grafman J. Executive functions. Handb Clin Neurol. 2019; 163:197-219. doi: 10.1016/B978-0-12-804281-6.00011-2. 
  2. Roebers CM. Executive function and metacognition: Towards a unifying framework of cognitive self-regulation. Dev Rev. 2017; 45:31-51. doi: 10.1016/j.dr.2017.04.001.
  3. Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev. 2000; 71(1):44-56. doi: 10.1111/1467-8624.00117.
  4. Miyake A, Friedman NP, Emerson, MJ, Witzki AH, Howerter A, Wager TD. The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: A latent variable analysis. Cogn Psychol. 2000; 41(1):49-100. doi: 10.1006/cogp.1999.0734.
  5. Diamond A. Executive functions. Annu Rev Psychol. 2013; 64:135-68. doi: 10.1146/annurev-psych-113011-143750.
  6. Morris N, Jones DM. Memory updating in working memory: The role of the central executive. British Journal of Psychology. 1990; 81(2):111-21. doi: 10.1111/j.2044-8295.1990.tb02349.x.
  7. Friedman NP, Miyake A, Corley RP, Young SE, DeFries JC, Hewitt JK. Not all executive functions are related to intelligence. Psychol Sci. 2006; 17(2): 172-9. doi: 10.1111/j.1467-9280.2006.01681.x.
  8. Zarghi A, Zali AR, Tehranidost M, Zarindast MR, Khodadadi SM. Application of cognitive computerized test in assessment of neuro-cognitive domain. Pejouhandeh. 2012; 16(5):241-5. [In Persian].
  9. Shagholian M, Azadfalah P, Fathie Ashtiani A, Khodadi M. Designing software version of Wisconsin Card Sorting Test Base of theory, Procedure of making and psychometric property. Clinical Psychology Studies. 2012; 1(4):110-34. [In Persian].
  10. Rezapour T, Soltani Nezhad Z, Ekhtiari Administration and scoring manual persian paper and Pencil Cognitive Assessment Package (PCAP)]. Tehran: Mehrsa Publication; 2013. [In Persian].
  11. Hofmann W, Schmeichel BJ, Baddeley AD. Executive functions and self-regulation. Trends Cogn Sci. 2012; 16(3):174-80. doi: 10.1016/j.tics.2012.01.006..
  12. Perini G, Ramusino MC, Sinforiani E, Bernini S, Petrachi R, Costa A. Cognitive impairment in depression: Recent advances and novel treatments. Neuropsychiatric Disease and Treatment. 2019; 15: 1249-58. doi: 10.2147/NDT.S199746.
  13. Scult MA, Paulli AR, Mazure ES, Moffitt TE, Hariri AR, Strauman TJ. The association between cognitive function and subsequent depression: A systematic review and meta-analysis. Psychol Med. 2017; 47(1):1-17. doi: 10.1017/S0033291716002075.
  14. Donovan NJ, Wu Q, Rentz DM, Sperling RA, Marshall GA, Glymour MM. Loneliness, depression and cognitive function in older U.S. adults. Int J Geriatr Psychiatry. 2017; 32(5):564-73. doi: 10.1002/gps.4495.
  15. Eskandari Z, Taremian F, Nazari MA, Bakhtiari M, Momtazi S, Rezaei M. Effectiveness of neurofeedback treatment to decrease severity symptoms in major depressive disorder. J Adv Med Biomed Res.. 2014; 22(92):86-95. [In Persian].
  16. Kirova AM, Bays RB, Lagalwar S. Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer’s disease. BioMed Res Int. 2015; 2015:748212. doi: 10.1155/2015/748212.
  17. Owen AM, McMillan KM, Laird AR, Bullmore E. N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp. 2005; 25(1):46-59. doi: 10.1002/hbm.20131.
  18. Dekker AD, Strydom A, Coppus AM, Nizetic D, Vermeiren Y, Naude PJ, et al. Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease. Cortex. 2015; 73:36-61. doi: 10.1016/j.cortex.2015.07.032.
  19. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association; 2013.
  20. Amitai N, Markou A. Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: Relevance to cognitive dysfunction in schizophrenia. Biol Psychiatry. 2010; 68(1):5-16. doi: 10.1016/j.biopsych.2010.03.004.
  21. Giraldo-Chica M, Rogers BP, Damon SM, Landman BA, Woodward ND. Prefrontal-thalamic anatomical connectivity and executive cognitive function in schizophrenia. Biol Psychiatry. 2018; 83(6):509-17. doi: 10.1016/j.biopsych.2017.09.022.
  22. Haller CS, Walder B. Severe neurotrauma in Switzerland: have short-term outcomes improved? Swiss Med Wkly. 2015; 145:w14177. doi: 10.4414/smw.2015.14177.
  23. Cristofori I, Grafman J. Chapter 18-Executive Functions After Traumatic Brain Injury: From deficit to recovery. Exec. Funct Health Dis. 2017; 2017:421- doi: 10.1016/B978-0-12-803676-1.00018-0.
  24. Azouvi P, Arnould A, Dromer E, Vallat-Azouvi C. Neuropsychology of traumatic brain injury: An expert Rev Neurol (Paris). 2017; 173(7-8):461-72. doi: 10.1016/j.neurol.2017.07.006.
  25. Lezak MD, Howieson DB, Bigler ED, Tranel D. Neuropsychological Assessment, 5th Edn. New York, NY: Oxford University Press; 2012.
  26. Chan RC, Shum D, Toulopoulou T, Chen EYH. Assessment of executive functions: Review of instruments and identification of critical issues. Arch Clin Neuropsychol. 2008; 23(2):201- doi: 10.1016/j.acn.2007.08.010.
  27. Nyongesa MK, Ssewanyana D, Mutua AM, Chongwo E, Scerif G, Newton CRJC, et al. Assessing executive function in adolescence: A scoping review of existing measures and their psychometric robustness. Front Psychol. 2019; 10:311. doi: 10.3389/fpsyg.2019.00311.
  28. Yntema DB. Keeping track of several things at once. Hum Factors. 1963; 5:7-17. doi: 10.1177/001872086300500102.
  29. Friedman NP, Miyake A, Young SE, DeFries JC, Corley RP, Hewitt JK. Indivisual differences in executive functions are almost entirely genetic in origin. J Exp Psychol Gen. 2008; 137(2):201-25. doi: 10.1037/0096-3445.137.2.201.
  30. Newman I, Lim J, Pineda Content validity using a mixed methods approach: Its application and development through the use of a table of specifications methodology. Journal of Mixed Methods Research. 2013; 7(3):243-60. doi 10.1177/1558689813476922.
  31. Mozafari M, Mehri nejad SA, Peyvstegar M, Saghafinia M. Investigating cognitive complications following of mild traumatic brain injury in executive function and working memory of patients. Journal of Cognitive Psychology. 2018; 6(3):31-40. [In Persian].
  32. Bartova L, Meyer BM, Diers K, Rabl U, Scharinger C, Popovic A, et al. Reduced default mode network suppression during a working memory task in remitted major depression. J Psychiatr Res. 2015; 64:9-18. doi: 10.1016/j.jpsychires.2015.02.025.
  33. Seif AA. Evaluation and assessment of educational progression. Tehran: Agah Publication; 1992. [In Persian].
  34. Friedman NP, Miyake A, Altamirano LJ, Corley RP, Young SE, Rhea SA, et al. Stability and change in executive function abilities from late adolescence to early adulthood: A longitudinal twin study. Dev Psychol. 2016; 52(2):326-40. doi: 10.1037/dev0000075.
  35. Ito TA, Freidman NP, Barthlow BD, Correll J, Loersch C, Altamirano LJ, et al. Toward a comprehensive understanding of executive cognitive function in implicit racial bias. J Pers Soc Psychol. 2015; 108(2):187-218. doi: 10.1037/a0038557
  36. Bhattacharya Cognitive function in Schizophrenia: A review. J Psychiatry. 2015; 18(1):1-8. doi: 10.4172/2378-5756.1000187.
  37. Schoonover KE, Dienel SJ, Lewis DA. Prefrontal cortical alterations of glutamate and GABA neurotransmission in Schizophrenia: Insights for rational biomarker development. Biomark Neuropsychiatry. 2020; 3:100015. doi: 10.1016/j.bionps.2020.100015.
  38. Rajji TK, Miranda D, Mulsant BH. Cognition, function, and disability in patients with Schizophrenia: A review of longitudinal studies. Can J Psychiatry. 2014; 59(1):13-7. doi: 10.1177/070674371405900104.
  39. Bedard M, Taler V, Steffener J. Long-term prospective memory impairment following mild traumatic brain injury with loss of consciousness: findings from the Canadian Longitudinal Study on Aging. Clin Neuropsychol. 2018; 32(5):1002-18. doi: 10.1080/13854046.2017.1404644.
  40. The Brain Injury Association. Executive Dysfunction after Brain Injury; 2020. Available online: http //www.headway.org.uk/media/2801/executive-dysfunction-after-brain-injury-factsheet.pdf. (accessed on 5 May 2020)
  41. Gagnon Working memory in Alzheimer's disease and Mild Cognitive Impairment (MCI): Assessment and intervention. [Dissertation]. Universite de Montreal; 2012. P. 154.
  42. Guarino A, Favieri F, Boncompagni I, Agostini F, Cantone M, Casagrande M. Executive functions in Alzheimer disease: A systematic review. Front Aging Neurosci. 2019; 10:437. doi: 10.3389/fnagi.2018.00437.
  43. Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer Arch Neurol. 2001; 58(9):1403-8. doi: 10.1001/archneur.58.9.1403.
  44. Mowlai M, Hatami J, Rostami R. The comparison of executive functions in obsessive-compulsive disorder and major depressive disorder patients with healthy individuals. Journal of Advances in Cognitive Science. 2014; 16(3):61-71. [In Persian].
  45. Warren SL, Heller W, Miller GA. The structure of executive 37 dysfunction in depression and anxiety. J Affect Disord. 2021; 279:208-16. doi: 10.1016/j.jad.2020.09.132.