Journal of Kerman University of Medical Sciences

Plasma Vitamin D level in Patients with SARS-CoV-2 Infection: Does it Correlates With the Increased Risk of Infection?

Document Type : Original Article

Authors

Nasrin Saberi 1
Behnam Dalfardi 2
Mitra Samareh Fekri 3
Meysam Yousefi 4
Mehrdad Farrokhnia 5
Mohammad Reza Shakibi 6
Mohamad Hasan Tajadini 7
Mohsen Shafiepour 5

1 Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

3 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

4 Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

5 Clinical Research Development Unit, Afzalipour Hospital‚ Kerman University of Medical Sciences‚ Kerman‚ Iran

6 Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

7 Department of Clinical Biochemistry, school of Medicine, Tarbiat Modares University, Tehran, Iran

https://doi.org/10.22062/jkmu.2022.91952
Abstract
Background: COVID-19 is a widespread viral disease that has severely affected our world. Although beneficial effects of vitamin D on immune system are well known, there are ongoing discussions about its role in patients suffering from SARS-CoV-2 infection. In this study, we examined the relationship between risk of COVID-19 infection and plasma vitamin D level.
Methods: This case-control study was conducted on 133 participants in Kerman city, Iran. SARS-CoV-2 infection was confirmed by positive RT-Real time PCR test in 69 cases and another 64 participants were considered as - non-infected - control group. Plasma vitamin D levels were measured among all, and compared.
Results: Sub-normal plasma vitamin D level were reported in about 51% of participants; however, there was no significant difference in the mean plasma vitamin D levels between COVID-19 and control groups. Mean plasma levels of vitamin D were significantly higher in females than males (P-value: 0.017).
Conclusion: According to our results, risk of COVID-19 infection does not correlate with plasma level of vitamin D.

Keywords

Keywords: COVID-19
Disease Severity
Pneumonia
SARS-CoV-2
Vitamin D Deficiency
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Journal of Kerman University of Medical Sciences
Volume 29, Issue 3
May and June 2022
Pages 281-287

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