Journal of Kerman University of Medical Sciences

The Relationship between Plasma Osteopontin Level and Proteinuria in Diabetic Patients

Document Type : Original Article

Authors

Farzaneh Najafi 1
Nasim Namiranian 2
Delaram Razavi 3
Javad Mohiti-Ardakani 4
Masoud Rahmanian 5
Roghaye Razavi 6
Somayeh Gholami 7

1 Nephrology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Community & Preventive Medicine, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Biotechnology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Biochemistry and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5 Endocrinology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

6 Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

7 Epidemiology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

https://doi.org/10.34172/jkmu.2023.26
Abstract
Background: Elevated serum levels of osteopontin (OPN) have been associated with cardiovascular disease, diabetic nephropathy, and autoimmune disease activity. The aim of this study was to investigate the relationship between OPN serum levels and renal damage in type 2 diabetes patients.
Methods: This analytical cross-sectional study was carried out in Yazd, Iran from April to September 2017. Micro-albuminuria and creatinine (Cr) in 750 patients were measured and 180 included patients were divided into the three groups of 60 subjects based on the level of micro-albuminuria; normal (group A), micro proteinuria (group B) and macro proteinuria (group C). Body weight, height, blood pressure, body mass index (BMI), HbA1c and OPN were assessed.
Results: Among 179 patients, 60 of them were normal for proteinuria, 59 patients had micro-proteinuria and 60 ones had macro- proteinuria. The mean age of participants was 58.96 ( ± 11.10) years (range 26-80 years), 90 patients (50.8%) were males and 88 ones (49.2%) were females. The mean OPN levels were significantly higher in group C compared to group B, and in group B compared to group A (P = 0.0001). Serum OPN was correlated positively with HbA1c (P: 0.012), Cr (P = 0.010) and glomerular filtration rate (GFR) (P = 0.002). There was a significant difference in the mean of OPN level among the subgroups with the history of ischemic heart disease (IHD) and HbA1C (P=0.035, and 0.047 respectively).
Conclusion: These findings suggest that OPN is involved in chronic disease activity, and there is an independent association between plasma levels of OPN, and nephropathy in diabetic patients.

Highlights

Farzaneh Najafi(Google scholar)(Pubmed)

Nasim Namiranian(Google scholar)(Pubmed)

Javad Mohiti-Ardakani(Google scholar)(Pubmed)

Masoud Rahmanian(Google scholar)(Pubmed)

RoghayeRazav(Google scholar)(Pubmed)

 Somayeh Gholami(Google scholar))(Pubmed)

Keywords

Type 2 diabetes
Nephropathy
Osteopontin

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Journal of Kerman University of Medical Sciences
Volume 30, Issue 3
May and June 2023
Pages 160-164

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