Introduction: Cetirizine is a second-generation antihistamine with the anti-allergy and anti-itching properties. Topical formulation of this medicine is used in androgenic alopecia treatment. Due to the hydrophilic nature of cetirizine, its skin absorption is negligible, so in order to increase its skin absorption, various enhancers were used so that they can be used in the design of a topical form.
Material and Methods: First, the skin was placed in contact with the enhancers such as Eucalyptus, Menthol, Tween 80, Propylene Glycol and Oleic acid for one or two hours, and then the permeability parameters of the cetirizine solution and also the structural changes of the skin after being exposed to enhancers were analyzed by DSC and FT-IR techniques.
Results: The obtained results show that all enhancers used have increased the permeability of the drug cetirizine compared to water. Various mechanisms such as liquefaction of lipids, destruction of lipid structure, as well as irreversible denaturation of intracellular keratin caused by Eucalyptus, Menthol, Tween 80, Propylene Glycol and Oleic acid, are the main mechanisms of increasing drug penetration.
Conclusions: Based on the results, it was determined that among the studied absorption enhancers, Eucalyptus and Tween 80 had the most and Propylene Glycol the least absorption enhancement effect in two- and one-hour pre-contact, respectively.