Document Type : Original Article
Authors
1 Clinical Research Development Center of Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
2 Student Research Committee, Arak University of Medical Sciences, Arak, Iran
3 Pediatric Oncology, Iran University of Medical Sciences, Tehran, Iran
Abstract
Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM.
Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard 12 lead electrocardiogram during a single study visit and the depolarization and repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2*less than 20 ms.
Results: A total of 26 patients (mean 26.19 years old, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15% <20 ms, 53.85% ≥20 ms). Among ECG parameters, only Pwd, QTc and QTcd (p: 0.026, 0.030, and 0.006 respectively) were significantly prolonged in patients with T2* < 20 ms compared to patients with T2*≥ 20 ms. There was a statistically negative Correlation between T2 * CMR and Pwd and QTcd (p: 0.028, and 0.021 respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc and T2* values.
Conclusions: PWD and QTcd can be used as an alternative to T2*CMR to predict cardiac iron load levels in patients with beta thalassemia major.
Highlights
yazdan ghandi(google scholar)(pubmd)
Bita Ghahremani(google scholar)(pubmd)
Aziz Eghbali(google scholar)(pubmd)
Parsa Yousefichaijan(google scholar)(pubmd)
Masoud Bahrami(google scholar)(pubmd)
Keywords
Main Subjects
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