Document Type : Original Article


1 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

2 Department of Physiology and Pharmacology, Afzali Pour School of Medicine and Physiology Research Center, Neuropharmacology Research Institute, Kerman University of Medical Sciences, Kerman, Iran


Background:The histone methyltransferase (SMYD1) and the muscle-specific protein (PERM1) play an important role in maintaining cardiac energetics and function. The present study aimed to examine the effect of two types of endurance training (running and swimming) plus MitoQ supplementation on gene expression of PERM1 and SMYD1 plus hemodynamic function in the cardiac muscle of male Wistar rats.
Methods: The animals underwent MitoQ supplementation or endurance training or endurance training + MitoQ supplementation for eight weeks. Gene expression of PERM1 and SMYD1, measured by Real Time-PCR and quantified by 2-∆∆CT method, and hemodynamic function were compared between groups using two-way multivariate analysis of variance.
Results: Cardiac gene expression of PERM1 and SMYD1 increased significantly through running (PERM1, P < 0.05; SMYD1, P < 0.01), swimming (PERM1, P < 0.05; SMYD1, P < 0.05). and MitoQ supplementation (PERM1, P < 0.001). The effects of MitoQ supplementation were additive to both running and swimming effects on cardiac gene expression of (PERM1, P < 0.001; SMYD1, P < 0.05). Swimming-induced enhancement in cardiac expression of PERM1 and SMYD1 was associated with a significant increase in ±dP/dt max (P < 0.05)).
Conclusion: Expression of genes involved in cardiac metabolism can be affected by endurance training and this effect could be improved through MitoQ supplementation


Main Subjects

mahboube salajeghe tezergi(google scholar)(pubmed)
Daruosh Moflehi(google scholar)(pubmed)
Soheil Aminizadeh(google scholar)(pubmed)
Rohollah Nikooie(google scholar)(pubmed)