Document Type : Original Article


1 Molecular and Medical Research Center, Arak University of Medical Sciences, Arak, Iran

2 Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

3 Department of Neurology, University of California, San Diego, USA

4 Department of Health and Nutrition, Islamic Azad University Arak Branch, Arak, Iran.

5 Biostatistician, Departmanof Biostatistics, Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.

6 Student research committee, Arak University of Medical Sciences, Arak, Iran


Background: Migraine is a complex neurological disorder. The precise etiology of migraine is not clear. Many studies have been conducted on the association of the immune system with migraine pathophysiology. Neurogenic inflammation as the main pathomechanisms of migraine is well described. The aim of this study was to evaluate the pattern of interleukin IL-1β , IL -17A, TAC and MDA in the migraine patients.
methods: In this case-control study, serum samples were taken from 31 migraine patients, who were referred to the neurology clinics of medical centers of Arak University of Medical Sciences. The severity of headache was assessed with standard questionnaires. Serum samples were also obtained from 30normal individuals. The levels of IL -1β and IL -17A were measured by a sensitive ELISA method. Total antioxidant capacity ) TAC (was measured by FRAP technique, also lipid peroxidation level was evaluated by the MDA assay. Data was analyzed descriptively and analytically by SPSS21 software.
Results: The results showed that the mean level of IL-1β in the case group was significantly higher than the control group (p =0.01). The mean level of IL-17A was not significantly different in the two groups. Mean serum MDA level in the study group was significantly higher than in the controls (P=0.005). No statistical difference was observed in mean serum level of TAC between two groups

Conclusion: It seems the pathogenesis of migraine can be associated with immune system function, and inhibition of pro-inflammatory cytokine production may be effective in the treatment of migraine patients.


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