Journal of Kerman University of Medical Sciences

Euglycemic Diabetic Ketoacidosis in a Type 2 Diabetic Patient Treated with Empagliflozin: Case Report

Document Type : Case Report

Authors

Reza Mohamad Hosein zade Davatgari 1
Mahsa Soti khiabani 2
Parviz Shahmirzalou 3
Maryam Habibi 4

1 Kashan university of medical sciences, Kashan, Iran.

2 children's medical center, Tehran university of medical sciences,Tehran,Iran.

3 School of Public Health, Khoy university of Medical Sciences, Khoy, Iran.

4 Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan,

https://doi.org/10.34172/jkmu.2023.50
Abstract
Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are a relatively novel class of oral medications for the treatment of Type 2 DM with a generally acceptable safety profile. Euglycemic DKA is a diagnostic challenge for physicians due to the variety of etiologies and normal blood glucose levels, often resulting in delayed diagnosis. Euglycemic ketoacidosis is a rare but rather serious complication of SGLT-2 inhibitors use, often with a multifactorial etiology. Its atypical presentation requires a high level of awareness by physicians as early recognition of this complication can quickly and safely restore acid-base balance. EuDKA is not identical with the typical diabetic ketoacidosis, as it often presents with serious metabolic acidosis but only mild to moderate glucose and anion gap elevation. Patients with type 1 or type 2 diabetes who experienced nausea, vomiting, malaise, or develop metabolic acidosis in the setting of SGLT-2 inhibitor therapy should be promptly evaluated for the presence of urine and/or serum ketones.

Highlights

Reza Mohamad Hosein zade Davatgari(googl scholar)(pubmed)

Mahsa Soti khiabani(googl scholar)(pubmed) 

Parviz Shahmirzalou(googl scholar)(pubmed) 

Maryam Habibi(googl scholar)(pubmed)

Keywords

SGLT2 inhibitors
diabetic ketoacidosis
euglycemia
Subjects
Journal of Kerman University of Medical Sciences
Volume 30, Issue 5
September and October 2023
Pages 296-299

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