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Destructive Effects of Formaldehyde on Mouse Ovaries Ameliorated by Rosa damascena

Document Type : Original Article

Authors

1 Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran

2 Department of Anatomical Sciences, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Laboratory Sciences, School of Medicine, Bam University of Medical Sciences, Bam, Iran

4 Pulmonology Department of Pediatrics Afzalipour Hospital, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

5 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Science, Kerman, Iran

6 Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran

7 Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran

Abstract

Background:  Formaldehyde (FA) is a chemical precursor that has toxic effects on several systems, including the reproductive system. Rosa damascena L. (RD) is an ancient herbal drug with various antioxidant substances. In the present study, the effects of RD on mouse ovaries against FA toxicity were investigated.
Methods: In this study, 48 adult female NMRI mice were included and divided randomly into six groups (n=8): control, 10% FA group received a single dose of FA (10 mg/kg which was diluted in normal saline) intraperitoneally (i.p), FA+RD10, FA+RD20, and FA+RD40 that received RD extract 10, 20, and 40 mg/kg/d orally, respectively, following FA injection, and RD40 that only received RD extract 40 mg/kg/d orally, without FA administration.
Results: After 40 days of treatment, estrogen and progesterone levels decreased in serum in the FA group relative to the normal group (P<0.001). Also, the ovary weight, volume and diameter (WVD), and number of different ovarian follicles were significantly reduced in the FA-treated group (P<0.05). Treatment of female mice with doses of 10, 20, and 40 RD improved the harmful effects of FA.
Conclusion: Based on the available evidence in this study, different doses of RD especially its low dose (10 mg/kg) can protect the ovaries against FA toxicity.

Keywords

Main Subjects

References
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Journal of Kerman University of Medical Sciences
Volume 32
Pages 1-6
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