Document Type : Original Article
Authors
- Ramin Hasani Yazdi 1
- Farshad Abedi 2
- Zeinab VafaeiPour 3, 4
- Sepehr Shirzad 1
- Mohammad Etezadpour 5
- Pouria Rahmanian-Devin 6
- AmirHoushang Mohamadpour 2
- Vahid Jomezadeh 1
1 Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3 Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5 Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6 Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: Peritoneal adhesion is a critical postsurgical complication in abdominal and pelvic surgeries. Due to their anti-inflammatory and fibrinolytic properties, statins are assumed to reduce peritoneal adhesions effectively. Our study aimed to investigate the effects of atorvastatin topical solution on preventing postoperative peritoneal adhesion in rats.
Methods: Twenty male Wistar rats were used, and a 2–3 cm ventral midline incision was made under general anesthesia. The cecal abrasion model was used for the induction of peritoneal adhesion. Four groups of five rats were used: normal saline (negative control), hydrocortisone 1% (positive control), atorvastatin 1%, and atorvastatin 4%. All rats were sacrificed on the fifth postoperative day. The adhesions were scored as 1 to 4 microscopically and 0 to 5 macroscopically. A histopathological study was performed on the cecum and adherent bands. A blood sample was also taken for high-sensitivity C-reactive protein (hs-CRP) analysis on day 5.
Results: Histopathological evaluation showed that microscopic and macroscopic adhesion significantly decreased after using atorvastatin 4% compared to the normal saline group (P = 0.032 and P = 0.008, respectively). Atorvastatin 4% also significantly reduced the level of hs-CRP after abdominal surgery (P = 0.001). The results with atorvastatin 1% were insignificant.
Conclusion: Atorvastatin 4% topical solution effectively prevented rat peritoneal adhesion, possibly through its anti-inflammatory effects. More extensive animal studies with atorvastatin and other statins and large human clinical trials are still needed to confirm the applicability and accuracy of the present findings.
Keywords
Main Subjects
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