Document Type : Case Report
Authors
1 Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Center for Disease Control, Deputy for Health, Kerman University of Medical Sciences, Kerman, Iran
4 Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract
Background: Cutaneous leishmaniasis is a parasitic infectious disease characterized by skin lesions and scarring. Although standard treatments are available, some patients experience treatment failure or exhibit inadequate therapeutic responses, highlighting the need for alternative or adjunctive therapies.
Case Report: This report describes the case of a 33-year-old woman with treatment-resistant cutaneous leishmaniasis who failed to respond to conventional therapies. The patient voluntarily opted to use the herbal topical product derived from Commiphora myrrha resin. The product was applied topically to the lesion twice daily. After six weeks of consistent application, the lesion healed completely without recurrence.
Conclusion: This case highlights the therapeutic potential of C. myrrha resin, which is known for its antiparasitic properties, as a primary treatment option for Leishmania major-induced cutaneous leishmaniasis and as an adjuvant therapy for L. tropica infections. Further research is warranted to validate its efficacy and explore its mechanisms of action in larger clinical studies.
Keywords
Main Subjects
- Nadim A, Mohebali M, Khamesipour A. Leishmania Parasite and Leishmaniases. Tehran: Tehran University of Medical Sciences; 2021.
- Shirzadi MR. Surveillance Guideline for Cutaneous Leishmaniasis in Iran. Tehran: Razenahan; 2012.
- Zakariya Razi M. Al-Mansouri fi al-Tibb. Transl. by Sadighi H. Tehran: Tehran University of Medical Sciences; 2008.
- Akhawayni R. Hedayat al-Motaallemin fi Tebb. Tehran: Choogan; 2018.
- Ibn Sina. Avicenna The Canon. Tehran: Soroush; 2010.
- Jorjani SE. Zakhireye Kharazmshahi. Tehran: Safirardehal ; 2019.
- Khan MA. Eksir-e-Azam. Tehran: Alma’ee; 2014.
- El Ashry ES, Rashed N, Salama OM, Saleh A. Components, therapeutic value and uses of myrrh. Pharmazie. 2003;58(3):163-8.
- Aghili Khorasani M. Makhzan al-Advieh [The Storehouse of Medicaments]. Tehran: Choogan; 2017.
- Batiha GE, Wasef L, Teibo JO, Shaheen HM, Zakariya AM, Akinfe OA, et al. Commiphora myrrh: a phytochemical and pharmacological update. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(3):405-20. doi: 10.1007/s00210-022- 02325-0.
- Madia VN, De Angelis M, De Vita D, Messore A, De Leo A, Ialongo D, et al. Investigation of Commiphora myrrha (Nees) Engl. oil and its main components for antiviral activity. Pharmaceuticals (Basel). 2021;14(3):243. doi: 10.3390/ ph14030243.
- Assimopoulou AN, Zlatanos SN, Papageorgiou VP. Antioxidant activity of natural resins and bioactive triterpenes in oil substrates. Food Chem. 2005;92(4):721-7. doi: 10.1016/j. foodchem.2004.08.033.
- Mohamed AA, Ali SI, El-Baz FK, Hegazy AK, Kord MA. Chemical composition of essential oil and in vitro antioxidant and antimicrobial activities of crude extracts of Commiphora myrrha Ind Crops Prod. 2014;57:10-6. doi: 10.1016/j. indcrop.2014.03.017.
- Abdul-Ghani RA, Loutfy N, Hassan A. Myrrh and trematodoses in Egypt: an overview of safety, efficacy and effectiveness profiles. Parasitol Int. 2009;58(3):210-4. doi: 10.1016/j. parint.2009.04.006.
- Awad MA, Al Olayan EM, Siddiqui MI, Merghani NM, Alsaif SS, Aloufi AS. Antileishmanial effect of silver nanoparticles: green synthesis, characterization, in vivo and in vitro assessment. Biomed Pharmacother. 2021;137:111294. doi: 10.1016/j.biopha.2021.111294.