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The Relationship Between Gender Difference and the Circadian Rhythm of Renal Function and Histopathology in an Adenine-Induced Kidney Disease Rat Model

Document Type : Original Article

Authors

1 Department of Medicine, Ke.C., Islamic Azad University, Kerman, Iran

2 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

4 Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, Iran

5 Endocrine and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

6 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

7 Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran

8 Department of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

9 Department of Anatomical Sciences, Kerman University of Medical Sciences, Kerman, Iran

10 Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Introduction: Chronic kidney disease (CKD) is characterized by progressive kidney damage and decreased renal function. There may be differences in the incidence of CKD between males and females. This study aimed to evaluate the variations in biochemical and pathological parameters, including induced circadian rhythm changes, in male and female rats with CKD.
Methods: 24 male, 24 intact female, and 24 ovariectomized female rats were divided into CKD and control groups, with two subgroups for each main group (n = 6). After inducing CKD, urine samples were collected at 12:00 a.m. (midnight) and 12:00 p.m. (noon) to measure urea, creatinine, and protein levels. The right kidneys were evaluated histopathologically. The data were analyzed using a three-way repeated-measures analysis of variance (ANOVA) and Bonferroni correction for post hoc analysis.
Results: CKD increased urine volume, urea, creatinine, urine protein levels, GFR, and histopathological indices compared to the control group at both time points. In addition, male rats exhibited more significant damage in renal function and structure at 12:00 p.m. compared with intact female and ovariectomized rats.
Conclusions: CKD and circadian rhythm both affect the physiological functions of the kidneys. However, sex differences potentially contribute to the development and progression of these changes.

Keywords

Main Subjects

References
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Journal of Kerman University of Medical Sciences
Volume 33
Pages 1-10
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