Document Type : Original Article
Authors
- Narges Dehghanimohammadabadi 1
- Abdulhamid Amooee 1
- Atiyeh Javaheri 2
- Hamid Owliaey 3
- Mohammad Amini 4
- Morteza Anvari 5
- Hamidreza Ghasemirad 6
1 Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of Medical Science, YMS. C., Islamic Azad University, Yazd, Iran
4 Department of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5 Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Introduction: Postoperative adhesions are a serious health problem with significant implications for quality of life and healthcare costs. This study aimed to investigate the effect of two substances, PerClot® Powder and Surgicel, in reducing adhesions after hysterectomy in rat models compared to the control group.
Methods: This study used an interventional laboratory trial design. The study population consisted of 30 adult female rats, which were randomly assigned to three groups (n = 10 per group) and underwent hysterectomy under standard conditions. The three groups received either Surgicel, PerClot®, or no treatment (control group). Adhesions were graded using the Leach grading system and analyzed using SPSS version 22, through the Chi-square test.
Results: No significant difference was found among the Surgicel, PerClot®, and control groups regarding adhesion grades (P = 0.064). However, a significant difference was observed between the Surgicel and control groups (P = 0.014). The Surgicel group had a higher frequency of grade 0 adhesions (60%) and no grade 2 adhesions, while the control group had a frequency of 10% for grade 0 adhesions and 50% for grade 2 adhesions. Additionally, no significant difference was found between the PerClot® and control groups (P = 0.214), indicating similar adhesion grade distributions. No significant difference was observed between the Surgicel and PerClot® groups (P = 0.301).
Conclusion: According to the findings, Surgicel significantly reduces adhesion severity compared to the control, while PerClot® does not show a significant effect. In addition, there is no significant difference between the Surgicel and PerClot® groups regarding adhesion.
Keywords
Main Subjects
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