Journal of Kerman University of Medical Sciences

Investigation of platelet-related parameters and BMI in children with cyanotic and non-cyanotic congenital heart disease

Document Type : Original Article

Authors

Mehran Akbari 1, 2
Reza Beiranvand 3
Masoud Bahrami 4
Yazdan Ghandi 4, 5

1 Nursing Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

2 Student Research Committee, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

3 Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran

4 Clinical Research Development Center, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran

5 Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran

https://doi.org/10.34172/jkmu.3896
Abstract
Background: Considering the role platelets play in hemostasis and coagulation, in the present study, we have examined platelet-related parameters and BMI in children with cyanotic and non-cyanotic CHD.
Methods: Fifty children with cyanotic and non-cyanotic CHD were investigated in this case-control study. Platelet-related parameters and other hematologic factors, weight, and BMI were evaluated.
Results: The findings indicated a notable disparity in hemoglobin levels between cyanotic and non-cyanotic cases, with respective mean values of 14.44 ± 2.64 and 12.66 ± 0.77 (p = 0.002). Also, the HCT was significantly higher in cyanotic CHD cases than in non-cyanotic cases (p = 0.002). The regression analysis revealed that cyanotic children had 0.41 times lower odds of having higher weights compared to non-cyanotic children. The mean Hb and HCT in cyanotic children were 1.77 and 7.48 units higher than in non-cyanotic children, and the difference was statistically significant (p = 0.002). The mean PDW in cyanotic children was 0.44 units lower than in non-cyanotic children, and the difference was statistically significant (p = 0.009), and the mean PLT in cyanotic children was 117.687 units lower than in non-cyanotic children, which was not statistically significant (p = 0.165).
Conclusion: Based on the present findings, the platelet indices, specifically PDW and PLT, showed a strong inverse correlation with hematocrit levels, indicating that elevated hematocrit directly affects blood clotting in CCHD. Also, the results showed that the likelihood of elevated weight was lower in cyanotic children compared to non-cyanotic children.

Highlights

Mehran Akbari (Google Scholar) (PubMed)

Yazdan Ghandi (Google Scholar) (PubMed)

Keywords

Platelet count
Platelet function
CHD
Cyanotic
Non-cyanotic
weight
BMI
Subjects
  1. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019;2019:9213074. doi: 10.1155/2019/9213074.
  2. Mohamed AB, Elnady HM, Alhewaig HK, Moslem Hefny H, Khodery A. The mean platelet volume and plateletcrit as predictors of short-term outcome of acute ischemic stroke. Egypt J Neurol Psychiatr Neurosurg. 2019;55(1):4. doi: 10.1186/s41983-018-0035-x.
  3. Lee E, Kim M, Jeon K, Lee J, Lee JS, Kim HS, et al. Mean platelet volume, platelet distribution width, and platelet count, in connection with immune thrombocytopenic purpura and essential thrombocytopenia. Lab Med. 2019;50(3):279-85. doi: 10.1093/labmed/lmy082.
  4. Akbari M, Bahrami M, Ghandi Y. Platelet indices in pediatrics with congenital heart disease with and without pulmonary arterial hypertension. J Kerman Univ Med Sci. 2024;32(1):1-6. doi: 10.34172/jkmu.3895.
  5. Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, et al. Transfusion practices in pediatric cardiac surgery requiring cardiopulmonary bypass: a secondary analysis of a clinical database. Pediatr Crit Care Med. 2021;22(11):978-87. doi: 10.1097/pcc.0000000000002805.
  6. Frid G, Reppucci M, Lum T, Paul M, Seiden H, Coakley BA. Comparison of necrotizing enterocolitis in pre-mature infants vs. term-born infants with congenital heart disease. Front Pediatr. 2021;9:802607. doi: 10.3389/fped.2021.802607.
  7. Gu L, Li YY, Gu L, Xie L, Liu HM. Idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease in Chinese children: similarities, differences, and prognostic factors. Front Pediatr. 2020;8:106. doi: 10.3389/fped.2020.00106.
  8. Cashen K, Dalton H, Reeder RW, Saini A, Zuppa AF, Shanley TP, et al. Platelet transfusion practice and related outcomes in pediatric extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2020;21(2):178-85. doi: 10.1097/ pcc.0000000000002102.
  9. Dieu A, Van Regemorter V, Detaille T, Houtekie L, Eeckhoudt S, Khalifa C, et al. Combined use of rotational thromboelastometry (ROTEM) and platelet impedance aggregometry (Multiplate analyzer) in cyanotic and acyanotic infants and children undergoing cardiac surgery with cardiopulmonary bypass: subgroup analysis of a randomized clinical trial. J Cardiothorac Vasc Anesth. 2021;35(7):2115- 23. doi: 10.1053/j.jvca.2020.09.133.
  10. Roche SL, Silversides CK. Hypertension, obesity, and coronary artery disease in the survivors of congenital heart disease. Can J Cardiol. 2013;29(7):841-8. doi: 10.1016/j.cjca.2013.03.021.
  11. Mohammedi Golwala Z, Shah H, Gupta N, Sreenivas V, Puliyel JM. Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci. 2016;16(2):356-62. doi: 10.4314/ahs. v16i2.3.
  12. Lill MC, Perloff JK, Child JS. Pathogenesis of thrombocytopenia in cyanotic congenital heart disease. Am J Cardiol. 2006;98(2):254-8. doi: 10.1016/j.amjcard.2006.01.083.
  13. Ismail EA, Youssef OI. Platelet-derived microparticles and platelet function profile in children with congenital heart disease. Clin Appl Thromb Hemost. 2013;19(4):424-32. doi: 10.1177/1076029612456733.
  14. Auluck A, Manohar C. Haematological considerations in patients with cyanotic congenital heart disease: a review. Dent Update. 2006;33(10):617-8, 20-2. doi: 10.12968/ denu.2006.33.10.617.
  15. Hussein HF, Al-Gohary EH, Mohamed AG, Abd El-Salam AA. Evaluation of red cell distribution width and platelet indices in children with chronic heart disease. Open J Pediatr. 2021;11(1):78-99. doi: 10.4236/ojped.2021.111008.
  16. Majumdar A, Biswas S, Jana A. Platelet indices as an earlier and economical marker of neonatal sepsis. Iraqi J Hematol. 2021;10(2):108-11. doi: 10.4103/ijh.ijh_15_21.
  17. Eswaran A, Kunnath AP, Hon GM, Ayob YA, Tharmajan P. Relationship between platelet indices and coronary heart disease in Malaysian population. J Biomed Sci. 2020;9(3):1-6. doi: 10.36648/2254-609X.9.3.6.
  18. Broberg CS, Jayaweera AR, Diller GP, Prasad SK, Thein SL, Bax BE, et al. Seeking optimal relation between oxygen saturation and hemoglobin concentration in adults with cyanosis from congenital heart disease. Am J Cardiol. 2011;107(4):595-9. doi: 10.1016/j.amjcard.2010.10.019.
  19. Khatab AA, Hassan FM, Habib MS, El-Zayat RS, Ali RS. Study of serum leptin level in children with cyanotic and acyanotic congenital heart disease. Menoufia Med J. 2020;33(1):152-6. doi: 10.4103/mmj.mmj_21_17.
  20. Al-Asy H, Donia A, El-Amrosy D, Rabee E, Al-Bendary A. The levels of ghrelin in children with cyanotic and acyanotic congenital heart disease. J Pediatr Sci. 2014;6:e209.
  21. Anagnostopoulou A, Eleftherakis N, Karanasios E. Obesity and underweight in children who undergo catheterization for congenital heart disease: a retrospective study. Glob Pediatr. 2024;7:100095. doi: 10.1016/j.gpeds.2023.100095.
  22. Sato M, Inai K, Ogiso M, Kudo Y, Nishimura T, Mori H, et al. Platelet volume indices correlate to severity of heart failure and have prognostic value for both cardiac and thrombotic events in patients with congenital heart disease. Eur Heart J. 2020;41(Suppl 2):ehaa946-2208. doi: 10.1093/ehjci/ ehaa946.2208.
  23. Martínez-Quintana E, Rodríguez-Hernández JL, Riaño-Ruiz M, Rodríguez-González F. Mean platelet volume and major adverse cardiovascular events in congenital heart disease patients. Clin Hemorheol Microcirc. 2019;72(4):327-37. doi: 10.3233/ch-180471.
  24. Majiyagbe OO, Akinsete AM, Adeyemo TA, Salako AO, Ekure EN, Okoromah CAN. Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a developing country. PLoS One. 2022;17(7):e0263948. doi: 10.1371/journal.pone.0263948.
  25. Houghton DE, Koh I, Ellis A, Key NS, Douce DR, Howard G, et al. Hemoglobin levels and coronary heart disease risk by age, race, and sex in the reasons for geographic and racial differences in stroke study (REGARDS). Am J Hematol. 2020;95(3):258-66. doi: 10.1002/ajh.25703.
  26. Sorlie PD, Garcia-Palmieri MR, Costas R Jr, Havlik RJ. Hematocrit and risk of coronary heart disease: the Puerto Rico Health Program. Am Heart J. 1981;101(4):456-61. doi: 10.1016/0002-8703(81)90136-8.
  27. Jin YZ, Zheng DH, Duan ZY, Lin YZ, Zhang XY, Wang JR, et al. Relationship between hematocrit level and cardiovascular risk factors in a community-based population. J Clin Lab Anal. 2015;29(4):289-93. doi: 10.1002/jcla.21767.
  28. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175(3):433-40. doi: 10.1016/j. ijcard.2014.06.028.

 

 

Journal of Kerman University of Medical Sciences
Volume 32
Pages 1-7

Home

Editorial Board

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us