Document Type : Original Article
Authors
- Nalini Devarajan 1
- Hema Palaniappan 2
- Karthick Rajendran 3
- Jhansi Nathan 4
- Ruskin Erusan 5
- E Susithra 6
- Mathangi R 7
1 Meenakshi Academy of Higher Education and Research
2 Department of Pharmacology, Govt. Coimbatore Medical College & Hospital,
3 Madras medical College,Chennai,Tamilnadu,India
4 INSPIRE Faculty, AUKBC Research Centre, Anna University, Chennai.
5 5Multidisciplinary Research Unit, Tirunelveli Medical College, Tirunelveli 627011, Tamil Nadu, India.
6 College of Pharmacy, University Accreditation Coordinator, Sri Venkateswara University, Chennai, Tamil Nadu, India.
7 Sree Balaji Dental College and Hospital
Abstract
Background: This study examined the impact of aqueous Aloe vera extracts on body weight, lipid storage in adipose tissues, and HDL protein expression in female Swiss albino mice subjected to diet-induced obesity. Methodology: The experiment involved four groups of mice under controlled conditions of temperature, humidity, and light. Group 1 served as the untreated control. Group 2 was fed a cholesterol-rich diet for 35 days to induce obesity. Group 3 received the same cholesterol-rich diet but was subsequently treated with Aloe vera extract for 15 days. Group 4 consisted of control mice administered Aloe vera extract for 15 days without prior dietary modifications. Results: Aloe vera treatment significantly reduced body weight in the obese mice. Lipid storage in adipose tissues also decreased following treatment, while HDL protein expression was notably enhanced. Conclusion: Aloe vera extracts enable significant body weight reduction, enhances lipolysis and increases HDL levels in mice model in diet induced obesity.
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