Journal of Kerman University of Medical Sciences

Acute Urinary Retention Associated with Trazodone: A Case Report

Document Type : Case Report

Authors

Seyed Hamzeh Hosseini 1
Hamed Ghazvini 2
Seyedeh Masoumeh Seyedhosseini Tamijani 2
Raheleh Rafaiee 3

1 Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran

3 Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran

https://doi.org/10.34172/jkmu.4068
Abstract
Introduction: Trazodone is an antidepressant that acts on multiple serotonin receptors, particularly 5‑HT2A and 5‑HT2C, contrib­uting to its antidepressant and anxiolytic effects. While most urinary side effects linked to trazodone involve incontinence, acute urinary retention is rarely reported. Pharmacological effects on serotonin receptors and possible anticholinergic-like activity may influence urinary function.
Case Report: We presented a 41‑year‑old woman treated with trazodone for depression and claustrophobia, who developed severe acute urinary retention lasting three days. The patient experienced difficulty initiating urination, with no prior urinary tract pathol­ogy. After discontinuation of trazodone, spontaneous urination resumed promptly and without recurrence.
Conclusion: Although acute urinary retention is an uncommon adverse effect of trazodone, clinicians should remain vigilant, particularly in patients with risk factors for impaired bladder emptying. Careful monitoring of urinary function may help prevent complications while ensuring effective treatment of psychiatric conditions.

Keywords

Case reports
Urinary retention
Trazodone
Subjects
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Journal of Kerman University of Medical Sciences
Volume 33
Pages 1-3

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