Document Type : Original Article
Authors
- Marzieh Ghasemi 1
- Vajihe Yazdani-Shahrbabaki 2
- Ayob Jabari 3
- Forough Forghani 4
- Firouzeh Rakhshani-Moghadam 4
- Abas-Ali Niazi 5
- Elnaz Salahi 4
- Tayebeh Dahmardeh 4
- Sadjad Yazdani 6
1 Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Department of Obstetrics and Gynecology, Moloud Infertility Treatment Center Zahedan University of Medical Sciences, Zahedan, Iran
2 Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran. Department of Obstetrics and Gynecology, Moloud Infertility Treatment Center Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Obstetrics and Gynecology, Moloud Infertility Treatment Center Zahedan University of Medical Sciences, Zahedan, Iran Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Cellular
4 Department of Obstetrics and Gynecology, Moloud Infertility Treatment Center Zahedan University of Medical Sciences, Zahedan, Iran
5 Department of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
6 School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
Abstract
Introduction: Frozen-thawed embryo transfer (FET) is widely employed in assisted reproduction, with endometrial preparation and monitoring being critical for improving live birth rates. However, optimizing cost-effectiveness remains essential.
Methods: This prospective cohort study involved 214 patients undergoing FET. Initially, subjects were administered received 6 mg oral estradiol valerate initially, with dose adjustments based on ultrasound-measured endometrial thickness. Endometrial transformation was achieved with 400 mg micronized vaginal progesterone (three times a day) for 5 days (blastocyst transfer) or 3 days (cleavage-stage transfer). Endometrial thickness was measured trans vaginaly before progesterone initiation and on transfer day. Serum concentrations of estradiol and progesterone were assessed on transfer day. Statistical analysis were performed to determine the associations between EC, hormone levels and the rate of chemical and ongoing pregnancies.
Results: Analysis of 214 FET cycles revealed no statically significant correlation between serum concentrations of estradiol, progesterone and pregnancy outcomes regardless embryo type. However, EC was notably linked to improved chemical, clinical, and ongoing pregnancy rates.
Conclusion: While serum estradiol and progesterone levels at the time of transfer did not influence pregnancy success, EC at transfer day significantly enhanced outcomes. These results underscore the importance of endometrial dynamics in FET protocols.
Highlights
Marzieh Ghasemi (Google Scholar) ( PubMed)
Vajihe Yazdani-Shahrbabaki (Google Scholar) ( PubMed)
Keywords
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