Document Type : Original Article
Authors
- Ali Hosseininasab 1
- Mehrdad Farokhnia 2
- Ali-Asghar Arabi Mianroodi 3
- Elham Iranmanesh 4
- Sobhan Mohammadi 5
- Adel Soltani 5
- Mehran Ilaghi 5
- Saja Shahdforush 5
- Alireza Hashemi 5
1 Associate Professor, Infectious and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran
2 Assistant Professor, Department of Internal Medicine, Infectious and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran
3 Assistant Professor, Department of Head and Neck Surgery, Kerman University of Medical Sciences, Kerman, Iran
4 MD, Department of Pediatrics. Resident of Pediatrics, Kerman University of Medical Sciences, Kerman, Iran
5 Medical Student, Kerman University of Medical Sciences, Kerman, Iran
Abstract
Background: Olfactory and gustatory dysfunctions can be considered as important symptoms to screen for the mild cases of the COVID-19 disease. However, there are limited studies on the specificity of olfactory and gustatory changes in patients with COVID-19, and it is unclear to what extent the changes may be unique to the disease. This study aimed to evaluate the duration and outcome of olfactory and gustatory disorders in patients with COVID-19.
Methods: The study population was patients with COVID-19 at Afzalipour Hospital whose disease was confirmed by nasopharyngeal polymerase chain reaction (PCR) test. 20 patients with olfactory and gustatory dysfunctions were studied. Data were collected using two forms, which were completed at the time of diagnosis and two weeks after the onset of the disease.
Results: In 20% of the patients, olfactory and gustatory dysfunctions were among the early symptoms. In 85% of the cases, these dysfunctions were permanent during the disease. 30% of the cases had a chronic underlying disease such as sinusitis, nasal polyps, and allergy. In follow-up, 13 patients (60%) reported that their olfactory dysfunctions had completely improved.
Conclusion: The patients whose only symptom is the sudden olfactory or gustatory dysfunction or the dysfunctions are among their early symptoms, should be screened for COVID-19. Most of the patients will recover over the time.
Keywords
- Samimi Ardestani SH, Mohammadi Ardehali M, Rabbani Anari M, Rahmaty B, Erfanian R, Akbari M, et al. The coronavirus disease 2019: the prevalence, prognosis, and recovery from olfactory dysfunction (OD). Acta Otolaryngol 2020; 141(2):171-80.
- van Riel D, Verdijk R, Kuiken T. The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. J Pathol 2015; 235(2):277-87.
- Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020; 277(8):2251-61.
- Izquierdo-Dominguez A, Rojas-Lechuga MJ, Mullol J, Alobid I. Olfactory dysfunction in the COVID-19 outbreak. J Investig Allergol Clin Immunol 2020; 30(5):30.
- Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngol Head Neck Surg 2020; 163(1):114-20.
- Otte MS, Klussmann JP, Luers JC. Persisting olfactory dysfunction in patients after recovering from COVID-19. J Infect 2020; 81(3):e58.
- D'Ascanio L, Pandolfini M, Cingolani C, Latini G, Gradoni P, Capalbo M, et al. Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell. Otolaryngol Head Neck Surg 2020; 164(1):82-6.
- Lechien JR, Cabaraux P, Chiesa-Estomba CM, Khalife M, Plzak J, Hans S, et al. Psychophysical olfactory tests and detection of COVID-19 in patients with sudden onset olfactory dysfunction: a prospective study. Ear Nose Throat J 2020; 99(9):579-83.
- Kosugi EM, Lavinsky J, Romano FR, Fornazieri MA, Luz-Matsumoto GR, Lessa MM, et al. Incomplete and late recovery of sudden olfactory dysfunction in COVID-19. Braz J Otorhinolaryngol 2020; 86(4):490-6.
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