Document Type : Short Communication
Professor of Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran
Department of Biochemistry, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Professor of Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Background: The aim of the present study was to evaluate the inhibition of α-glucosidase and antioxidant properties of different tissues of sea urchin Echinometra mathaei.
Methods: α-glucosidase inhibition was determined using p-Nitrophenyl-a-D-glucopyranoside as a substrate, and the antioxidant properties were evaluated by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS),1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide radicals scavenging. Also, antioxidant potential was evaluated by the ferric reducing antioxidant power (FRAP) method.
Results: Among the studied tissues, the highest α-glucosidase inhibition was revealed by the ethyl acetate extract of the shell and Aristotle’s lantern (IC50 = 3.7 and 4 mg/mL, respectively). Shell had the highest ABTS (IC50 = 183) and DPPH (IC50 = 208 μg/mL) radicals scavenging, respectively. And, gonad had the highest antioxidant potential by the FRAP method (1140 μg ASA/mg) and NO radical scavenging (70.68%), respectively.
Conclusion: Antidiabetic potentials of the ethyl acetate extracts of sea urchin tissues suggest that these extracts can be used as antidiabetic drugs.