Antidiabetic and Antioxidant Properties of Sea Urchin Echinometra mathaei from the Persian Gulf

Document Type : Short Communication

Authors

1 Professor of Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran

2 Department of Biochemistry, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran

3 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Professor of Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

10.22062/jkmu.2021.91569

Abstract

Background: The aim of the present study was to evaluate the inhibition of α-glucosidase and antioxidant properties of different tissues of sea urchin Echinometra mathaei.
Methods: α-glucosidase inhibition was determined using p-Nitrophenyl-a-D-glucopyranoside as a substrate, and the antioxidant properties were evaluated by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS),1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide radicals scavenging. Also, antioxidant potential was evaluated by the ferric reducing antioxidant power (FRAP) method.
Results: Among the studied tissues, the highest α-glucosidase inhibition was revealed by the ethyl acetate extract of the shell and Aristotle’s lantern (IC50 = 3.7 and 4 mg/mL, respectively). Shell had the highest ABTS (IC50 = 183) and DPPH (IC50 = 208 μg/mL) radicals scavenging, respectively. And, gonad had the highest antioxidant potential by the FRAP method (1140 μg ASA/mg) and NO radical scavenging (70.68%), respectively.
Conclusion: Antidiabetic potentials of the ethyl acetate extracts of sea urchin tissues suggest that these extracts can be used as antidiabetic drugs.

Keywords


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